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Elena Verdú, MD, PhD

Associate Professor, Department of Medicine

Canada Research Chair in Inflammation, Microbiota and Nutrition

Director of the Axenic Gnotobiotic Unit

Email: verdue@mcmaster.ca

Lab web site: www.verdulab.ca

Research Areas

I am interested in the pathogenesis of chronic inflammatory disorders such as celiac disease and inflammatory bowel disease. I investigate dietary-bacterial interactions and how this impacts the pathogenesis of gastrointestinal disease, with the view to develop novel therapeutic strategies for these disorders.

Focus

The main focus of research is to study host-microbial and dietary interactions and their role in the pathophysiology of chronic gastrointestinal inflammatory diseases. Work in my lab deals with the way commensal bacteria and food components interact with host tissues to enhance or prevent susceptibility to inflammation. We use a variety of molecular, mouse humanized models and clinical translational approaches to determine whether and how gluten-induced immunopathology is modulated by the small intestinal microbiota. Another important research interest investigates the role of the intestinal microbiota in the induction of mucosal barrier dysfunction and immune responses in the host that are of relevance in inflammatory bowel disease development. As director of the Axenic Gnotobiotic Facility at McMaster, we rederive transgenic mouse strains of interest to perform gnotobiotic colonizations using clinical isolates. The long term goal is to identify novel therapeutic targets to treat celiac disease and inflammatory bowel disease.

  1. McCarville, JL, Dong, J, Caminero, A, Bermudez-Brito, M, Jury, J, Murray, JA et al.. A commensal Bifidobacterium longum strain improves gluten-related immunopathology in mice through expression of a serine protease inhibitor. Appl. Environ. Microbiol. 2017; :. doi: 10.1128/AEM.01323-17. PubMed PMID:28778891 .
  2. Pinto-Sánchez, MI, Causada-Calo, N, Bercik, P, Ford, AC, Murray, JA, Armstrong, D et al.. Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies. Gastroenterology. 2017;153 (2):395-409.e3. doi: 10.1053/j.gastro.2017.04.009. PubMed PMID:28431885 .
  3. Thevaranjan, N, Puchta, A, Schulz, C, Naidoo, A, Szamosi, JC, Verschoor, CP et al.. Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host Microbe. 2017;21 (4):455-466.e4. doi: 10.1016/j.chom.2017.03.002. PubMed PMID:28407483 PubMed Central PMC5392495.
  4. Verdu, EF, Caminero, A. How infection can incite sensitivity to food. Science. 2017;356 (6333):29-30. doi: 10.1126/science.aan1500. PubMed PMID:28385972 .
  5. Bai, JC, Verdú, EF. The CD That Pays Dividends: More Than 15 Years of Deamidated Gliadin Peptide Antibodies. Dig. Dis. Sci. 2017;62 (5):1110-1112. doi: 10.1007/s10620-017-4528-8. PubMed PMID:28315033 .
  6. De Palma, G, Lynch, MD, Lu, J, Dang, VT, Deng, Y, Jury, J et al.. Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. Sci Transl Med. 2017;9 (379):. doi: 10.1126/scitranslmed.aaf6397. PubMed PMID:28251905 .
  7. Pinto-Sánchez, MI, Smecuol, EC, Temprano, MP, Sugai, E, González, A, Moreno, ML et al.. Bifidobacterium infantis NLS Super Strain Reduces the Expression of α-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients. J. Clin. Gastroenterol. 2017;51 (9):814-817. doi: 10.1097/MCG.0000000000000687. PubMed PMID:27636409 .
  8. Pinto-Sánchez, MI, Verdú, EF. Non-coeliac gluten sensitivity: are we closer to separating the wheat from the chaff?. Gut. 2016;65 (12):1921-1922. doi: 10.1136/gutjnl-2016-312471. PubMed PMID:27531827 .
  9. Rey, M, Yang, M, Lee, L, Zhang, Y, Sheff, JG, Sensen, CW et al.. Addressing proteolytic efficiency in enzymatic degradation therapy for celiac disease. Sci Rep. 2016;6 :30980. doi: 10.1038/srep30980. PubMed PMID:27481162 PubMed Central PMC4969619.
  10. Pinto-Sánchez, MI, Nachman, FD, Fuxman, C, Iantorno, G, Hwang, HJ, Ditaranto, A et al.. Altered Esophageal Mucosal Structure in Patients with Celiac Disease. Can J Gastroenterol Hepatol. 2016;2016 :1980686. doi: 10.1155/2016/1980686. PubMed PMID:27446827 PubMed Central PMC4904646.
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