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Jan D. Huizinga, PhD

Jan D. Huizinga, PhD

Professor, Department of Medicine

Email: huizinga@mcmaster.ca

  • Physiology and pharmacology of gastrointestinal motility
  • Cellular and molecular basis of peristalsis and mixing motor patterns
  • Effects of inflammation and gut bacteria on motility

Focus

  • Electrophysiology of gut pacemaker cells
  • Effect of probiotics and nutrients on gut motility control
  • Pathophysiology of gut motor disorders
  • Interactions between gut pacemaker cells and the enteric nervous system
  • In vivo and ex vivo measurements of motility

Project 1 CIHR, 2010-2015
Title: Role of interstitial cells of Cajal in control of gastrointestinal motility

Project 2 NSERC 2010-2011
Title: Potassium channels and ICC excitability

  1. Beck, K, Voussen, B, Reigl, A, Vincent, AD, Parsons, SP, Huizinga, JD et al.. Cell-specific effects of nitric oxide on the efficiency and frequency of long distance contractions in murine colon. Neurogastroenterol. Motil. 2019; :e13589. doi: 10.1111/nmo.13589. PubMed PMID:30947401 .
  2. Huizinga, JD, Parsons, SP. Pacemaker network properties determine intestinal motor pattern behaviour. Exp. Physiol. 2019; :. doi: 10.1113/EP087465. PubMed PMID:30834572 .
  3. Hanman, A, Chen, JH, Parsons, SP, Huizinga, JD. Noradrenaline inhibits neurogenic propulsive motor patterns but not neurogenic segmenting haustral progression in the rabbit colon. Neurogastroenterol. Motil. 2019;31 (5):e13567. doi: 10.1111/nmo.13567. PubMed PMID:30761706 .
  4. Zhu, YF, Kwiecien, JM, Dabrowski, W, Ungard, R, Zhu, KL, Huizinga, JD et al.. Cancer pain and neuropathic pain are associated with A β sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord. Mol Pain. ;14 :1744806918810099. doi: 10.1177/1744806918810099. PubMed PMID:30324862 PubMed Central PMC6243409.
  5. Chen, JH, Parsons, SP, Shokrollahi, M, Wan, A, Vincent, AD, Yuan, Y et al.. Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry. Front Physiol. 2018;9 :1248. doi: 10.3389/fphys.2018.01248. PubMed PMID:30294277 PubMed Central PMC6159752.
  6. Vincent, AD, Wang, XY, Parsons, SP, Khan, WI, Huizinga, JD. Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin. Am. J. Physiol. Gastrointest. Liver Physiol. 2018;315 (5):G896-G907. doi: 10.1152/ajpgi.00237.2017. PubMed PMID:30095295 .
  7. Parsons, SP, Huizinga, JD. Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut. J. Physiol. (Lond.). 2018;596 (20):4819-4829. doi: 10.1113/JP273425. PubMed PMID:30055053 PubMed Central PMC6187044.
  8. Chen, JH, Huizinga, JD. High-Pressure Tactic: Colonic Manometry in Chronic Constipation. Dig. Dis. Sci. 2018;63 (11):2820-2822. doi: 10.1007/s10620-018-5160-y. PubMed PMID:29881907 .
  9. Parsons, SP, Huizinga, JD. Slow wave contraction frequency plateaux in the small intestine are composed of discrete waves of interval increase associated with dislocations. Exp. Physiol. 2018;103 (8):1087-1100. doi: 10.1113/EP086871. PubMed PMID:29860720 .
  10. Huizinga, JD, Mathewson, KJ, Yuan, Y, Chen, JH. Probing heart rate variability to determine parasympathetic dysfunction. Physiol Rep. 2018;6 (10):e13713. doi: 10.14814/phy2.13713. PubMed PMID:29845773 PubMed Central PMC5974730.
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