Jan D. Huizinga, PhD

Jan D. Huizinga, PhD

Professor, Department of Medicine


  • Physiology and pharmacology of gastrointestinal motility
  • Cellular and molecular basis of peristalsis and mixing motor patterns
  • Effects of inflammation and gut bacteria on motility


  • Electrophysiology of gut pacemaker cells
  • Effect of probiotics and nutrients on gut motility control
  • Pathophysiology of gut motor disorders
  • Interactions between gut pacemaker cells and the enteric nervous system
  • In vivo and ex vivo measurements of motility

Project 1 CIHR, 2010-2015
Title: Role of interstitial cells of Cajal in control of gastrointestinal motility

Project 2 NSERC 2010-2011
Title: Potassium channels and ICC excitability

  1. Hanman, A, Chen, JH, Parsons, SP, Huizinga, JD. Noradrenaline inhibits neurogenic propulsive motor patterns but not neurogenic segmenting haustral progression in the rabbit colon. Neurogastroenterol. Motil. 2019; :e13567. doi: 10.1111/nmo.13567. PubMed PMID:30761706 .
  2. Zhu, YF, Kwiecien, JM, Dabrowski, W, Ungard, R, Zhu, KL, Huizinga, JD et al.. Cancer pain and neuropathic pain are associated with A β sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord. Mol Pain. ;14 :1744806918810099. doi: 10.1177/1744806918810099. PubMed PMID:30324862 PubMed Central PMC6243409.
  3. Chen, JH, Parsons, SP, Shokrollahi, M, Wan, A, Vincent, AD, Yuan, Y et al.. Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry. Front Physiol. 2018;9 :1248. doi: 10.3389/fphys.2018.01248. PubMed PMID:30294277 PubMed Central PMC6159752.
  4. Vincent, AD, Wang, XY, Parsons, SP, Khan, WI, Huizinga, JD. Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin. Am. J. Physiol. Gastrointest. Liver Physiol. 2018;315 (5):G896-G907. doi: 10.1152/ajpgi.00237.2017. PubMed PMID:30095295 .
  5. Parsons, SP, Huizinga, JD. Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut. J. Physiol. (Lond.). 2018;596 (20):4819-4829. doi: 10.1113/JP273425. PubMed PMID:30055053 PubMed Central PMC6187044.
  6. Chen, JH, Huizinga, JD. High-Pressure Tactic: Colonic Manometry in Chronic Constipation. Dig. Dis. Sci. 2018; :. doi: 10.1007/s10620-018-5160-y. PubMed PMID:29881907 .
  7. Parsons, SP, Huizinga, JD. Slow wave contraction frequency plateaux in the small intestine are composed of discrete waves of interval increase associated with dislocations. Exp. Physiol. 2018;103 (8):1087-1100. doi: 10.1113/EP086871. PubMed PMID:29860720 .
  8. Huizinga, JD, Mathewson, KJ, Yuan, Y, Chen, JH. Probing heart rate variability to determine parasympathetic dysfunction. Physiol Rep. 2018;6 (10):e13713. doi: 10.14814/phy2.13713. PubMed PMID:29845773 PubMed Central PMC5974730.
  9. Zhu, YF, Ungard, R, Zacal, N, Huizinga, JD, Henry, JL, Singh, G et al.. Rat model of cancer-induced bone pain: changes in nonnociceptive sensory neurons in vivo. Pain Rep. 2017;2 (4):e603. doi: 10.1097/PR9.0000000000000603. PubMed PMID:29392218 PubMed Central PMC5741358.
  10. Parsons, SP, Huizinga, JD. The phase response and state space of slow wave contractions in the small intestine. Exp. Physiol. 2017;102 (9):1118-1132. doi: 10.1113/EP086373. PubMed PMID:28671737 .
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