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Basic Research


We would like to welcome Darlene McCann as the new Administrator of the Farncombe Family Digestive Health Research Institute. Darlene has worked at McMaster University for over 12 years, first in the office of the Dean & Vice-President, Faculty of Health Sciences, and then in the office of the Associate Dean, ...


Inflammatory bowel diseases (IBD) are chronic, inflammatory conditions of the gastrointestinal tract and consist of Crohn?s disease (CD) and ulcerative colitis (UC). ...


Functional gastrointestinal disorders such as Irritable Bowel Syndrome are the most common form of digestive disease in seen our society. ...


Obesity can lead to insulin resistance, which precedes and predicts high blood glucose and type 2 diabetes. Obesity increases chronic inflammation leading to insulin resistance in tissues such as fat and liver that help control blood glucose. ...


Microbes such as bacteria, living within the gastrointestinal tract are important for food digestion, protection from pathogens, and have recently been implicated in disease risk...


The intimate relationship between the gut and brain is reflected clinically by the high prevalence of psychiatric disorders in patients with gastrointestinal diseases that are either inflammatory or functional in origin. There is also growing awareness of the prevalence of G.I....


At birth, we are colonized with a complex community of microbes, ten-times the number of human cells. Normally, these microbes exist in a mutualistic relationship with the host, are critical for growth and development...


The gut contains hundreds of thousands of endocrine cells which react to changes in gut contents by releasing hormones and variety of bioactive peptides. These hormones and peptides regulate intestinal motility and secretion and also modulate activity of mucosal immune cells....


Lifestyle choices, including diet and nutrition, influence the composition of the microbiota and its development following birth, which may have important implications for health and disease in both the young and the elderly. ...


The microorganisms living on and in our bodies are intimately involved in many aspects of our health: food digestion, protection from pathogens, development and interaction with our immune system....


Normal gastrointestinal motility is critical for the absorption of fluid and nutrients that sustain life. Coordinated gastrointestinal motility requires communication between the nerve and muscle layers of the gastrointestinal tract,...

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