The Surette lab is beaming after hearing that Maggie Williams, a grade 11 student from Ancaster high school, won a Gold Medal at this year’s Bay Area Science and Education Fair. Maggie has spent the last 4 months working in the Surette lab on her project entitled The Role of Fabric in the Prevention of Nosocomial Illness: Environmentally-Friendly Solutions. As part of her project, Maggie exposed various types of bacteria, including E.coli and Staphylococcus aureus, to different types of fabrics to see which were best able to prevent their growth. According to her research, fabrics made from natural fibres touted to have antibacterial activity did not prevent bacterial survival; however, silver and copper impregnated fabric did kill these bacteria. Hospital garments made of antibacterial fabric could reduce nosocomial transmission of pathogens.
Read more here
At BASEF 2016, the Bay Area High School Science fair, grade 11 student Ruihan Wei, working with Jan Huizinga and Sean Parsons won big with “Properties of the Intestinal Pacemaker Network revealed by Mathematical Modeling”. The project received the Best Biology Project award, the Mu Alpha Theta award for most creative mathematics project, the Mohawk Mathematics award and the BASEF Gold Medal award. Congratulation Ruihan!
The Healthy bugs for healthy babies DOHaD team, integrated by Dr. Sloboda (PI) and the co-apps: Atkinson, Barker, Bowdish, Braun, McConnell, McDonald, Moffat, Murray-Davis, Ratcliffe, Schertzer, Steegers-Theunissen, and Surette was awarded a 5 year funding of $1.5 million by CIHR.
Maternal obesity and/or excess gestational weight gain are primary risk factors for childhood obesity and metabolic compromise, perpetuating a feed forward cycle of chronic disease risk for future generations. In this program we ask, how is it that exposure to an obesogenic environment in utero gives rise to children that are destined to become obese and what are the signalling pathways? Excess adipose is associated with chronic low-grade inflammation, which has been implicated in many chronic diseases such as diabetes. It is also associated with significant changes in gut health; where changes in the composition of intestinal bacterial communities are associated with inflammation in metabolic tissues. We hypothesise that similarly, during pregnancy, excess adiposity changes the bacterial populations in a mothers gut and that these changes could cause placental inflammation modifying placental and/or fetal development, predisposing offspring to obesity and chronic disease.
In this integrative multidisciplinary program we will evaluate basic biological pathways that regulate gut health and immunity in pregnancy, and whether these pathways are impaired in pregnancies characterized by excess adiposity. We will use both animal models to understand molecular mechanisms and human studies to investigate relationships between adiposity, pregnancy weight gain and the maternal gut bacteria to uncover novel pathways that mediate the early origins of childhood obesity. We will take our data, and translate it into an informative community-based, fully-developed, intervention program to support diet and lifestyle improvement in women before and during pregnancy, with a special focus on high risk populations.
The IMAGINE Network, which stands for Inflammation, Microbiome, and Alimentation: Gastro-Intestinal and Neuropsychiatric Effects, is led by Dr. Paul Moayyedi, professor of medicine and clinical research lead of the Farncombe Family Digestive Health Research Institute. IMAGINE will be developing innovative therapies and novel probiotics for Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD).
Funding is from the Canadian Institutes for Health Research (CIHR) under Canada’s Strategy for Patient-Oriented Research (SPOR). With 17 centres across Canada and 75 team members, this SPOR network will be a patient-centred investigation that engages patients as partners, focusing on patient-identified priorities to improve their health outcome, identify new treatments, and deliver a more effective health care system to Canadians.
See the official press release here
Farncombe faculty and trainees will be highlighting their work at Canadian Digestive Diseases Week (CDDW), the annual scientific conference of the Canadian Association of Gastroenterology (CAG) in Montreal from February 23 – 26th. See below for details of the talks and session involving Farncombe members.
- Alberto Caminero Fernandez: Small intestinal bacteria determine gluten metabolism and immunogenicity
- Premysl Bercik: What do I do with my degree and training: Work-life balance as a PI
- Paul Moayyedi: Microbiota Directed Therapies for IBD: Focus on transplantation
- Grigorios Leontiadis: Long-term Risks of Proton Pump Inhibitors: What should I tell my patient?
- Jan Huizinga: 1. Mechanisms Underlying Colonic Motility. 2. Small Group Session on Colonic Motility
- David Armstrong: 1. Small Group CDHF Session: Protecting the Human Gut Microbiota to Enhance Health. 2. Small Group Session on Unusual Causes of Abdominal Pain
- Jennifer Stearns: Small Group Session on Bioinformatics and the Microbiome
- John Marshall: Should We Still Be Using Steroids and Immunosuppressants to Treat IBD?
Poster of Distinction
E. Denou , J. Ghia , H. Wang , J. Kim , M. Shajib , M. Shah , M. Surett , S. Collins & W. Khan “THE SEROTONERGIC ENDOCRINE- GUT MICROBIOTA AXIS IN EXPERIMENTAL COLITIS.”
CAG SYMPOSIUM – 2015 Papers That Influenced Your Practice
John Marshall – Vande Casteele N, Ferrante M, Van Assche G, et al. Trough concentrations of infliximab guide dosing for patients with inflammatory bowel disease. Gastroenterology 2015;148(7):1320-9.
John Marshall – Khanna R, Bressler B, Levesque BG, et al. Early combined immunosuppression for the management of Crohn’s disease (REACT): A cluster randomised controlled trial. Lancet. 2015 Sep 2. pii: S0140-6736(15)00068-9.
The McMaster Student Outreach and the Farncombe Social Committee want to say THANK YOU to everyone that helped raise enough goods to fill 20 gift bags to overflowing with personal care products, mittens, hats, gift cards, food and toys!
And a special THANK YOU to all of those that participated in December’s holiday bake sale. The proceeds were used to purchase gift cards for the gift bags and to help kickstart fundraising for the 2016 Crohn’s and Colitis Gutsy Walk.
Thanks again from your social committee!
Updates by the McMaster Student Outreach can be found on Facebook
The Joint Programming Initiative (JPI) “A Healthy Diet for a Healthy Life” (JPI HDHL) Strategic Research Agenda aims to contribute to joint research activities in the area of intestinal microbiome reasearch and encourage sharing and integration of data as a means to understand human diet-gut microbiome interactions. Six teams, made up of partners from two or more countries each, were awarded three years of funding for research programs that propose “to develop dietary interventions or guidance for modulation of the intestinal microbiome to promote health and/or prevent the development of non-communicable chronic diseases”. We are proud to announce that two of the six grants were awarded to members of the Farncombe Institute:
Elena Verdu as the principal Canadian investigator along with partners Philippe Langella and Harry Sokol in France and Jerry Wells in the Netherlands are funded to explore the effect of diet and the microbiome on the aryl hydrocarbon receptor (AhR), a transcription factor recently shown to be crucial for the maintenance of intestinal homeostasis. The overall aim of their project is to assess the effects of AhR activation by microbiota-derived components on intestinal immunity and physiology. They will determine the dietary-microbiota interactions that lead to AhR activation and identify AhR-activating microorganisms, or their metabolites, with potential health benefits.
Mike Surette and Jennifer Stearns as co-investigators on a
From left: Eileen Hutton, Julia Simioni, Katherine Morrison, Elizabeth Gunn and Jennifer Stearns.
grant lead by Eileen Hutton (the principal Canadian investigator) and Katherine Morrison, along with their international partners, are funded to study the intersection of gastrointestinal microbial communities, diet and health. The aim of their project is to determine the effects of the timing and nature of solid-food introduction and cessation of breast-milk on the succession and stability of the gut microbiome during a critical time period of maturation and subsequent health outcomes among cohorts of both term and preterm infants. Other Farncombe and McMaster co-investigators on this grant include: Jon Schertzer, Elyanne Ratcliffe, Alison Holloway, Helen McDonald and Lehana Thabane.
This summer Dr. Elena Verdu became the Present-Elect of the North American Society for the Study of Celiac Disease. The NASSCD’s mission is to advance the fields of celiac disease and gluten-related disorders by fostering research and by promoting excellence in clinical care, including diagnosis and treatment of patients with these conditions. Pictured here (from left) is the past president Joe Murray from the Mayo Clinic, Peter Green from the Celiac Disease Center at Columbia University, our very own Dr. Verdu, and Stefano Gandalini of the University of Chicago.