Functional GI Disease


Paul Moayyedi was involved in a large National Institute of Health funded multicentre randomized controlled trial of antidepressant therapy in functional dyspepsia led by the Mayo clinic. Premsyl Bercik has conducted a phase 2 randomized trial assessing a novel probiotic in patients with mood disorders and irritable bowel syndrome (IBS) and recently completed a pilot study showing the ability of a probiotic bacterium to improve depression in patients with IBS. He has also led a CIHR funded study that has evaluated a cohort of patients with IBS and correlated changes in symptoms with changes in the gut micro biome. John Marshall and Stephen Collins led a series of investigations on the impact of the large outbreak of water poisoning in the town of Walkerton, Ontarion and the development of post-infectious IBS. These studies described the epidemiology, pathophysiology and genetic predisposition to PI-IBS over an 8 year period.

People working in this area

Relevant Papers

  • Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. -
    Talley Nicholas J, Locke G Richard, Saito Yuri A et al.
    Gastroenterology. Link: 25921377
  • The Rome III criteria for the diagnosis of functional dyspepsia in secondary care are not superior to previous definitions. -
    Ford Alexander C, Bercik Premysl, Morgan David G et al.
    Gastroenterology. Link: 24417817
  • Validation of the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care. -
    Ford Alexander C, Bercik Premysl, Morgan David G et al.
    Gastroenterology. Link: 23994201
  • Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery. -
    Marshall John K, Thabane Marroon, Garg Amit X et al.
    Gut. Link: 20427395
  • Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis. -
    Villani Alexandra-Chloé, Lemire Mathieu, Thabane Marroon et al.
    Gastroenterology. Link: 20044998
  • Irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior. -
    Ford Alexander C, Forman David, Bailey Alastair G et al.
    Am J Gastroenterol. Link: 18371141

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