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Upper Gastrointestinal Diseases

Introduction

The Barrett’s clinic has involved patients in one of the world’s largest randomized trials of this disease evaluating whether we can prevent esophageal cancer using aggressive acid suppression and/or aspirin. Paul Moayyedi is deputy or co-principal investigator in two Barrett’s trials that have enrolled a total of over 5,000 patients. He was also a lead investigator of a study of population Helicobater pylori testing and treatment that evaluated over 8,400 subjects and followed them for over 10 years. David Armstrong was involved in the development of widely accepted international classification systems for both Barrett’s esophagus and gastro-esophageal reflux disease.

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Relevant Papers

  • Acid-suppressive therapy with esomeprazole for relief of unexplained chest pain in primary care: a randomized, double-blind, placebo-controlled trial. - 2013
    Flook Nigel W, Moayyedi Paul, Dent John et al.
    Am J Gastroenterol. Link: 23147520
  • Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial. Leeds HELP Study Group. - 2000
    Moayyedi P, Feltbower R, Brown J et al.
    Lancet. Link: 10905240
  • The gain in quality-adjusted life months by switching to esomeprazole in those with continued reflux symptoms in primary care: EncomPASS--a cluster-randomized trial. - 2010
    Moayyedi Paul, Armstrong David, Hunt Richard H et al.
    Am J Gastroenterol. Link: 20842110
  • Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study. - 2010
    Ford Alexander C, Thabane Marroon, Collins Stephen M et al.
    Gastroenterology. Link: 20117111
  • Helicobacter pylori test and treat versus proton pump inhibitor in initial management of dyspepsia in primary care: multicentre randomised controlled trial (MRC-CUBE trial). - 2008
    Delaney Brendan C, Qume Michelle, Moayyedi Paul et al.
    BMJ. Link: 18310262
  • A community screening program for Helicobacter pylori saves money: 10-year follow-up of a randomized controlled trial. - 2005
    Ford Alexander C, Forman David, Bailey Alastair G et al.
    Gastroenterology. Link: 16344059
  • Ethnicity, gender, and socioeconomic status as risk factors for esophagitis and Barrett's esophagus. - 2005
    Ford Alexander C, Forman David, Reynolds P Dominic et al.
    Am J Epidemiol. Link: 16076833
  • The gain in quality-adjusted life months by switching to esomeprazole in those with continued reflux symptoms in primary care: EncomPASS--a cluster-randomized trial. - 2010
    Moayyedi Paul, Armstrong David, Hunt Richard H et al.
    Am J Gastroenterol. Link: 20842110







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