Galipeau HJ, McCarville JL, Huebener S, Litwin O, Meisel M, Jabri B, Sanz Y, Murray JA, Jordana M, Alaedini A, Chirdo FG, Verdu EF. Am. J. Pathol. 2015. Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. The recent increase in CD incidence suggests that additional environmental factors, such as intestinal microbiota alterations, are involved in its pathogenesis.
Collins J, Borojevic R, Verdu EF, Huizinga JD, Ratcliffe EM. Normal gastrointestinal function depends on an intact and coordinated enteric nervous system (ENS). While the ENS is formed during fetal life, plasticity persists in the postnatal period during which the gastrointestinal tract is colonized by bacteria.
De Palma G, Blennerhassett P, Lu J, Deng Y, Park AJ, Green W, Denou E, Silva MA, Santacruz A, Sanz Y, Surette MG, Verdu EF, Collins SM, Bercik P Nat Commun 2015;6:7735 PMID: 26218677 Abstract Early-life stress is a determinant of vulnerability to a variety of disorders that include dysfunction of the brain and gut.
Bercik P, Collins SM Adv. Exp. Med. Biol. 2014;817:279-89 PMID: 24997039 Abstract Animal studies have demonstrated that the early phase of enteric infection is accompanied by anxiety-like behavior, which is mediated through vagal ascending pathways. Chronic infection alters gut function, including motility and visceral sensitivity, as well as feeding patterns, anxiety and depression-like behavior. These
Collins SM, Surette M, Bercik P Nat. Rev. Microbiol. 2012 Nov;10(11):735-42 PMID: 23000955 Abstract The intestinal microbiota consists of a vast bacterial community that resides primarily in the lower gut and lives in a symbiotic relationship with the host. A bidirectional neurohumoral communication system, known as the gut-brain axis, integrates the host gut and brain
Hoffmann AR, Proctor LM, Surette MG, Suchodolski JS Vet. Pathol. 2015 Jul; PMID: 26220947 Abstract The microbiome is the complex collection of microorganisms, their genes, and their metabolites, colonizing the human and animal mucosal surfaces, digestive tract, and skin. It is now well known that the microbiome interacts with its host, assisting in digestion and
Stearns JC, Davidson CJ, McKeon S, Whelan FJ, Fontes ME, Schryvers AB, Bowdish DM, Kellner JD, Surette MG ISME J 2015 May;9(5):1268 PMID: 25897775 Abstract