Paul Moayyedi, BSc, MB ChB, PhD, MPH, FRCP, FRCPC, FACG, AGAF

Professor, Department of Medicine
Director of Clinical Research, Farncombe Family Digestive Health Research Institute
Director, Division of Gastroenterology


Health Services Research in Gastroenterology


Dr. Moayyedi has a strong interest in evidence based medicine. He qualified in Medicine from Bristol University, UK and obtained a PhD in Medicine as well as a Master’s in Public Health from the University of Leeds, UK. He was appointed Director of the Division of Gastroenterology in 2006. He has conducted a number of large randomized controlled trials and epidemiological studies that have evaluated functional and organic disease of the GI tract. He has also published several systematic reviews that have been influential in British, American and Canadian national guidelines. He is the joint Coordinating Editor for the Upper Gastrointestinal and Pancreatic Diseases Cochrane Review Group based at McMaster and is also Co-Editor-in-Chief of the American Journal of Gastroenterology.


Epidemiology, biostatistics, systematic review and meta-analysis, clinical trials, health economics, decision modeling.

Project 1

Title: Aspirin and PPIs to prevent mortality in Barrett’s patients
Funders: Cancer Research UK and AstraZeneca
Role: Deputy Principal Investigator
Duration: 2004-2014

Project 2

Title: Barrett’s esophagus two yearly surveillance vs. no surveillance: a randomized controlled trial to estimate cost-effectiveness (BOSS)
Funders: National NHS R&D HTA program
Role: Principal Investigator
Duration: 2008-2019

Project 3

Title: The Michael J. Howorth GEM Project
Funders: Crohn’s and Colitis Foundation of Canada
Role: GEM Executive Team
Duration: 2007-2013

Project 4

Title: Cohort study of inflammatory bowel disease after acute enteric infection in Walkerton, Ontario.
Funders: Crohn’s and Colitis Foundation of Canada
Role: Co-investigator (Principal Investigator Dr. John Marshall)
Duration: 2005-2008

  1. Kanno, T, Moayyedi, P. Imipramine for functional dyspepsia: a 60-year journey. Lancet Gastroenterol Hepatol. 2018; :. doi: 10.1016/S2468-1253(18)30338-8. PubMed PMID:30361079 .
  2. Pittayanon, R, Yuan, Y, Bollegala, NP, Khanna, R, Lacy, BE, Andrews, CN et al.. Prokinetics for Functional Dyspepsia: A Systematic Review and Meta-analysis of Randomized Control Trials. Am. J. Gastroenterol. 2018; :. doi: 10.1038/s41395-018-0258-6. PubMed PMID:30337705 .
  3. Pittayanon, R, Yuan, Y, Bollegala, NP, Khanna, R, Leontiadis, GI, Moayyedi, P et al.. Prokinetics for functional dyspepsia. Cochrane Database Syst Rev. 2018;10 :CD009431. doi: 10.1002/14651858.CD009431.pub3. PubMed PMID:30335201 .
  4. Ford, AC, Harris, LA, Lacy, BE, Quigley, EMM, Moayyedi, P. Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome. Aliment. Pharmacol. Ther. 2018;48 (10):1044-1060. doi: 10.1111/apt.15001. PubMed PMID:30294792 .
  5. Chen, JH, Parsons, SP, Shokrollahi, M, Wan, A, Vincent, AD, Yuan, Y et al.. Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry. Front Physiol. 2018;9 :1248. doi: 10.3389/fphys.2018.01248. PubMed PMID:30294277 PubMed Central PMC6159752.
  6. Yongwen Ng, J, Chauhan, U, Armstrong, D, Marshall, J, Tse, F, Moayyedi, P et al.. A Comparison of the Prevalence of Anxiety and Depression Between Uncomplicated and Complex IBD Patient Groups. Gastroenterol Nurs. ;41 (5):427-435. doi: 10.1097/SGA.0000000000000338. PubMed PMID:30272605 .
  7. Ford, AC, Lacy, BE, Harris, LA, Quigley, EM, Moayyedi, P. Effect of Antidepressants and Psychological Therapies in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis. Am. J. Gastroenterol. 2018; :. doi: 10.1038/s41395-018-0222-5. PubMed PMID:30177784 .
  8. Black, CJ, Burr, NE, Quigley, EMM, Moayyedi, P, Houghton, LA, Ford, AC et al.. Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-analysis. Gastroenterology. 2018; :. doi: 10.1053/j.gastro.2018.08.021. PubMed PMID:30144426 .
  9. Steinhart, AH, Panaccione, R, Targownik, L, Bressler, B, Khanna, R, Marshall, JK et al.. Clinical Practice Guideline for the Medical Management of Perianal Fistulizing Crohn's Disease: The Toronto Consensus. Inflamm. Bowel Dis. 2018; :. doi: 10.1093/ibd/izy247. PubMed PMID:30099529 .
  10. Jankowski, JAZ, de Caestecker, J, Love, SB, Reilly, G, Watson, P, Sanders, S et al.. Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial. Lancet. 2018;392 (10145):400-408. doi: 10.1016/S0140-6736(18)31388-6. PubMed PMID:30057104 PubMed Central PMC6083438.
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