Paul Moayyedi, BSc, MB ChB, PhD, MPH, FRCP, FRCPC, FACG, AGAF

Professor, Department of Medicine
Director of Clinical Research, Farncombe Family Digestive Health Research Institute
Director, Division of Gastroenterology


Health Services Research in Gastroenterology


Dr. Moayyedi has a strong interest in evidence based medicine. He qualified in Medicine from Bristol University, UK and obtained a PhD in Medicine as well as a Master’s in Public Health from the University of Leeds, UK. He was appointed Director of the Division of Gastroenterology in 2006. He has conducted a number of large randomized controlled trials and epidemiological studies that have evaluated functional and organic disease of the GI tract. He has also published several systematic reviews that have been influential in British, American and Canadian national guidelines. He is the joint Coordinating Editor for the Upper Gastrointestinal and Pancreatic Diseases Cochrane Review Group based at McMaster and is also Co-Editor-in-Chief of the American Journal of Gastroenterology.


Epidemiology, biostatistics, systematic review and meta-analysis, clinical trials, health economics, decision modeling.

Project 1

Title: Aspirin and PPIs to prevent mortality in Barrett’s patients
Funders: Cancer Research UK and AstraZeneca
Role: Deputy Principal Investigator
Duration: 2004-2014

Project 2

Title: Barrett’s esophagus two yearly surveillance vs. no surveillance: a randomized controlled trial to estimate cost-effectiveness (BOSS)
Funders: National NHS R&D HTA program
Role: Principal Investigator
Duration: 2008-2019

Project 3

Title: The Michael J. Howorth GEM Project
Funders: Crohn’s and Colitis Foundation of Canada
Role: GEM Executive Team
Duration: 2007-2013

Project 4

Title: Cohort study of inflammatory bowel disease after acute enteric infection in Walkerton, Ontario.
Funders: Crohn’s and Colitis Foundation of Canada
Role: Co-investigator (Principal Investigator Dr. John Marshall)
Duration: 2005-2008

  1. Pinto-Sánchez, MI, Causada-Calo, N, Bercik, P, Ford, AC, Murray, JA, Armstrong, D et al.. Safety of Adding Oats to a Gluten-free Diet for Patients with Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies. Gastroenterology. 2017; :. doi: 10.1053/j.gastro.2017.04.009. PubMed PMID:28431885 .
  2. Sood, R, Gracie, DJ, Gold, MJ, To, N, Pinto-Sanchez, MI, Bercik, P et al.. Editorial: latent class analysis to improve confidence in the diagnosis of IBS - authors' reply. Aliment. Pharmacol. Ther. 2017;45 (9):1268-1269. doi: 10.1111/apt.14012. PubMed PMID:28370047 .
  3. Simpkins, SJ, Pintos-Sanchez, MI, Moayyedi, P, Bercik, P, Morgan, DG, Bolino, C et al.. Letter: NICE referral criteria for lower gastrointestinal alarm features - not ideal but not poor either. Authors' reply. Aliment. Pharmacol. Ther. 2017;45 (8):1176. doi: 10.1111/apt.13996. PubMed PMID:28326581 .
  4. Boghossian, TA, Rashid, FJ, Thompson, W, Welch, V, Moayyedi, P, Rojas-Fernandez, C et al.. Deprescribing versus continuation of chronic proton pump inhibitor use in adults. Cochrane Database Syst Rev. 2017;3 :CD011969. doi: 10.1002/14651858.CD011969.pub2. PubMed PMID:28301676 .
  5. Saito, YA, Locke, GR, Almazar, AE, Bouras, EP, Howden, CW, Lacy, BE et al.. Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial. Am. J. Gastroenterol. 2017; :. doi: 10.1038/ajg.2017.52. PubMed PMID:28291238 .
  6. Pinto-Sanchez, MI, Yuan, Y, Bercik, P, Moayyedi, P. Proton pump inhibitors for functional dyspepsia. Cochrane Database Syst Rev. 2017;3 :CD011194. doi: 10.1002/14651858.CD011194.pub2. PubMed PMID:28271513 .
  7. MacQueen, G, Surette, M, Moayyedi, P. The gut microbiota and psychiatric illness. J Psychiatry Neurosci. 2017;42 (2):75-77. . PubMed PMID:28245172 PubMed Central PMC5373703.
  8. Vege, SS, Ziring, B, Jain, R, Scheiman, JM, Hwang, JH, Moayyedi, P et al.. Optimal strategies for pancreatic cyst surveillance: we need better comparative data, not more case series. Gastrointest. Endosc. 2017;85 (3):685-686. doi: 10.1016/j.gie.2016.09.007. PubMed PMID:28215775 .
  9. Sood, R, Gracie, DJ, Gold, MJ, To, N, Pinto-Sanchez, MI, Bercik, P et al.. Derivation and validation of a diagnostic test for irritable bowel syndrome using latent class analysis. Aliment. Pharmacol. Ther. 2017;45 (6):824-832. doi: 10.1111/apt.13949. PubMed PMID:28105700 .
  10. Herrine, SK, Moayyedi, P, Brown, RS Jr, Falck-Ytter, YT. American Gastroenterological Association Institute Technical Review on Initial Testing and Management of Acute Liver Disease. Gastroenterology. 2017;152 (3):648-664.e5. doi: 10.1053/j.gastro.2016.12.027. PubMed PMID:28061338 .
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