Jan D. Huizinga, PhD

Jan D. Huizinga, PhD

Professor, Department of Medicine


  • Physiology and pharmacology of gastrointestinal motility
  • Cellular and molecular basis of peristalsis and mixing motor patterns
  • Effects of inflammation and gut bacteria on motility


  • Electrophysiology of gut pacemaker cells
  • Effect of probiotics and nutrients on gut motility control
  • Pathophysiology of gut motor disorders
  • Interactions between gut pacemaker cells and the enteric nervous system
  • In vivo and ex vivo measurements of motility

Project 1 CIHR, 2010-2015
Title: Role of interstitial cells of Cajal in control of gastrointestinal motility

Project 2 NSERC 2010-2011
Title: Potassium channels and ICC excitability

  1. Vincent, AD, Wang, XY, Parsons, SP, Khan, WI, Huizinga, JD. ABNORMAL ABSORPTIVE COLONIC MOTOR ACTIVITY IN GERM FREE MICE IS RECTIFIED BY BUTYRATE, AN EFFECT POSSIBLY MEDIATED BY MUCOSAL SEROTONIN. Am. J. Physiol. Gastrointest. Liver Physiol. 2018; :. doi: 10.1152/ajpgi.00237.2017. PubMed PMID:30095295 .
  2. Chen, JH, Huizinga, JD. High-Pressure Tactic: Colonic Manometry in Chronic Constipation. Dig. Dis. Sci. 2018; :. doi: 10.1007/s10620-018-5160-y. PubMed PMID:29881907 .
  3. Parsons, SP, Huizinga, JD. Slow wave contraction frequency plateaux in the small intestine are composed of discrete waves of interval increase associated with dislocations. Exp. Physiol. 2018; :. doi: 10.1113/EP086871. PubMed PMID:29860720 .
  4. Huizinga, JD, Mathewson, KJ, Yuan, Y, Chen, JH. Probing heart rate variability to determine parasympathetic dysfunction. Physiol Rep. 2018;6 (10):e13713. doi: 10.14814/phy2.13713. PubMed PMID:29845773 PubMed Central PMC5974730.
  5. Zhu, YF, Ungard, R, Zacal, N, Huizinga, JD, Henry, JL, Singh, G et al.. Rat model of cancer-induced bone pain: changes in nonnociceptive sensory neurons in vivo. Pain Rep. 2017;2 (4):e603. doi: 10.1097/PR9.0000000000000603. PubMed PMID:29392218 PubMed Central PMC5741358.
  6. Parsons, SP, Huizinga, JD. The phase response and state space of slow wave contractions in the small intestine. Exp. Physiol. 2017;102 (9):1118-1132. doi: 10.1113/EP086373. PubMed PMID:28671737 .
  7. Huizinga, JD. The powerful advantages of extracellular electrical recording. Nat Rev Gastroenterol Hepatol. 2017;14 (6):372. doi: 10.1038/nrgastro.2017.16. PubMed PMID:28356577 .
  8. Huizinga, JD. Commentary: Phase-amplitude coupling at the organism level: The amplitude of spontaneous alpha rhythm fluctuations varies with the phase of the infra-slow gastric basal rhythm. Front Neurosci. 2017;11 :102. doi: 10.3389/fnins.2017.00102. PubMed PMID:28303088 PubMed Central PMC5332408.
  9. Chen, JH, Yu, Y, Yang, Z, Yu, WZ, Chen, WL, Yu, H et al.. Intraluminal pressure patterns in the human colon assessed by high-resolution manometry. Sci Rep. 2017;7 :41436. doi: 10.1038/srep41436. PubMed PMID:28216670 PubMed Central PMC5316981.
  10. Quan, X, Yang, Z, Xue, M, Chen, JH, Huizinga, JD. Relationships between motor patterns and intraluminal pressure in the 3-taeniated proximal colon of the rabbit. Sci Rep. 2017;7 :42293. doi: 10.1038/srep42293. PubMed PMID:28195136 PubMed Central PMC5307310.
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