- Physiology and pharmacology of gastrointestinal motility
- Cellular and molecular basis of peristalsis and mixing motor patterns
- Effects of inflammation and gut bacteria on motility
Focus
- Electrophysiology of gut pacemaker cells
- Effect of probiotics and nutrients on gut motility control
- Pathophysiology of gut motor disorders
- Interactions between gut pacemaker cells and the enteric nervous system
- In vivo and ex vivo measurements of motility
Project 1 CIHR, 2010-2015
Title: Role of interstitial cells of Cajal in control of gastrointestinal motility
Project 2 NSERC 2010-2011
Title: Potassium channels and ICC excitability
- Hanman, A, Chen, JH, Parsons, SP, Huizinga, JD. Noradrenaline inhibits neurogenic propulsive motor patterns but not neurogenic segmenting haustral progression in the rabbit colon. Neurogastroenterol. Motil. 2019; :e13567. doi: 10.1111/nmo.13567. PubMed PMID:30761706 .
- Zhu, YF, Kwiecien, JM, Dabrowski, W, Ungard, R, Zhu, KL, Huizinga, JD et al.. Cancer pain and neuropathic pain are associated with A β sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord. Mol Pain. ;14 :1744806918810099. doi: 10.1177/1744806918810099. PubMed PMID:30324862 PubMed Central PMC6243409.
- Chen, JH, Parsons, SP, Shokrollahi, M, Wan, A, Vincent, AD, Yuan, Y et al.. Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry. Front Physiol. 2018;9 :1248. doi: 10.3389/fphys.2018.01248. PubMed PMID:30294277 PubMed Central PMC6159752.
- Vincent, AD, Wang, XY, Parsons, SP, Khan, WI, Huizinga, JD. Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin. Am. J. Physiol. Gastrointest. Liver Physiol. 2018;315 (5):G896-G907. doi: 10.1152/ajpgi.00237.2017. PubMed PMID:30095295 .
- Parsons, SP, Huizinga, JD. Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut. J. Physiol. (Lond.). 2018;596 (20):4819-4829. doi: 10.1113/JP273425. PubMed PMID:30055053 PubMed Central PMC6187044.
- Chen, JH, Huizinga, JD. High-Pressure Tactic: Colonic Manometry in Chronic Constipation. Dig. Dis. Sci. 2018; :. doi: 10.1007/s10620-018-5160-y. PubMed PMID:29881907 .
- Parsons, SP, Huizinga, JD. Slow wave contraction frequency plateaux in the small intestine are composed of discrete waves of interval increase associated with dislocations. Exp. Physiol. 2018;103 (8):1087-1100. doi: 10.1113/EP086871. PubMed PMID:29860720 .
- Huizinga, JD, Mathewson, KJ, Yuan, Y, Chen, JH. Probing heart rate variability to determine parasympathetic dysfunction. Physiol Rep. 2018;6 (10):e13713. doi: 10.14814/phy2.13713. PubMed PMID:29845773 PubMed Central PMC5974730.
- Zhu, YF, Ungard, R, Zacal, N, Huizinga, JD, Henry, JL, Singh, G et al.. Rat model of cancer-induced bone pain: changes in nonnociceptive sensory neurons in vivo. Pain Rep. 2017;2 (4):e603. doi: 10.1097/PR9.0000000000000603. PubMed PMID:29392218 PubMed Central PMC5741358.
- Parsons, SP, Huizinga, JD. The phase response and state space of slow wave contractions in the small intestine. Exp. Physiol. 2017;102 (9):1118-1132. doi: 10.1113/EP086373. PubMed PMID:28671737 .
