Jan D. Huizinga, PhD

Jan D. Huizinga, PhD

Professor, Department of Medicine


  • Physiology and pharmacology of gastrointestinal motility
  • Cellular and molecular basis of peristalsis and mixing motor patterns
  • Effects of inflammation and gut bacteria on motility


  • Electrophysiology of gut pacemaker cells
  • Effect of probiotics and nutrients on gut motility control
  • Pathophysiology of gut motor disorders
  • Interactions between gut pacemaker cells and the enteric nervous system
  • In vivo and ex vivo measurements of motility

Project 1 CIHR, 2010-2015
Title: Role of interstitial cells of Cajal in control of gastrointestinal motility

Project 2 NSERC 2010-2011
Title: Potassium channels and ICC excitability

  1. Zhu, YF, Ungard, R, Zacal, N, Huizinga, JD, Henry, JL, Singh, G et al.. Rat model of cancer-induced bone pain: changes in nonnociceptive sensory neurons in vivo. Pain Rep. 2017;2 (4):e603. doi: 10.1097/PR9.0000000000000603. PubMed PMID:29392218 PubMed Central PMC5741358.
  2. Parsons, SP, Huizinga, JD. The phase response and state space of slow wave contractions in the small intestine. Exp. Physiol. 2017;102 (9):1118-1132. doi: 10.1113/EP086373. PubMed PMID:28671737 .
  3. Huizinga, JD. The powerful advantages of extracellular electrical recording. Nat Rev Gastroenterol Hepatol. 2017;14 (6):372. doi: 10.1038/nrgastro.2017.16. PubMed PMID:28356577 .
  4. Huizinga, JD. Commentary: Phase-amplitude coupling at the organism level: The amplitude of spontaneous alpha rhythm fluctuations varies with the phase of the infra-slow gastric basal rhythm. Front Neurosci. 2017;11 :102. doi: 10.3389/fnins.2017.00102. PubMed PMID:28303088 PubMed Central PMC5332408.
  5. Chen, JH, Yu, Y, Yang, Z, Yu, WZ, Chen, WL, Yu, H et al.. Intraluminal pressure patterns in the human colon assessed by high-resolution manometry. Sci Rep. 2017;7 :41436. doi: 10.1038/srep41436. PubMed PMID:28216670 PubMed Central PMC5316981.
  6. Quan, X, Yang, Z, Xue, M, Chen, JH, Huizinga, JD. Relationships between motor patterns and intraluminal pressure in the 3-taeniated proximal colon of the rabbit. Sci Rep. 2017;7 :42293. doi: 10.1038/srep42293. PubMed PMID:28195136 PubMed Central PMC5307310.
  7. Wei, R, Parsons, SP, Huizinga, JD. Network properties of interstitial cells of Cajal affect intestinal pacemaker activity and motor patterns, according to a mathematical model of weakly coupled oscillators. Exp. Physiol. 2017;102 (3):329-346. doi: 10.1113/EP086077. PubMed PMID:28036151 .
  8. Mikkelsen, HB, Huizinga, JD, Larsen, JO, Kirkeby, S. Ionized calcium-binding adaptor molecule 1 positive macrophages and HO-1 up-regulation in intestinal muscularis resident macrophages. Anat Rec (Hoboken). 2017;300 (6):1114-1122. doi: 10.1002/ar.23517. PubMed PMID:27860408 PubMed Central PMC5484384.
  9. Huizinga, JD. A Personal Perspective on the Development of Our Understanding of the Myogenic Control Mechanisms of Gut Motor Function. Adv. Exp. Med. Biol. 2016;891 :11-9. doi: 10.1007/978-3-319-27592-5_2. PubMed PMID:27379630 .
  10. Carr, EC, Watt-Watson, J, McGillion, M, Huizinga, A. The quest of pain education leaders in Canada and the United States: a qualitative study. J Adv Nurs. 2016;72 (11):2728-2737. doi: 10.1111/jan.13050. PubMed PMID:27322620 .
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