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Jan D. Huizinga, PhD

Jan D. Huizinga, PhD

Professor, Department of Medicine

Email: huizinga@mcmaster.ca

  • Physiology and pharmacology of gastrointestinal motility
  • Cellular and molecular basis of peristalsis and mixing motor patterns
  • Effects of inflammation and gut bacteria on motility

Focus

  • Electrophysiology of gut pacemaker cells
  • Effect of probiotics and nutrients on gut motility control
  • Pathophysiology of gut motor disorders
  • Interactions between gut pacemaker cells and the enteric nervous system
  • In vivo and ex vivo measurements of motility

Project 1 CIHR, 2010-2015
Title: Role of interstitial cells of Cajal in control of gastrointestinal motility

Project 2 NSERC 2010-2011
Title: Potassium channels and ICC excitability

  1. Huizinga, JD. The powerful advantages of extracellular electrical recording. Nat Rev Gastroenterol Hepatol. 2017;14 (6):372. doi: 10.1038/nrgastro.2017.16. PubMed PMID:28356577 .
  2. Huizinga, JD. Commentary: Phase-amplitude coupling at the organism level: The amplitude of spontaneous alpha rhythm fluctuations varies with the phase of the infra-slow gastric basal rhythm. Front Neurosci. 2017;11 :102. doi: 10.3389/fnins.2017.00102. PubMed PMID:28303088 PubMed Central PMC5332408.
  3. Chen, JH, Yu, Y, Yang, Z, Yu, WZ, Chen, WL, Yu, H et al.. Intraluminal pressure patterns in the human colon assessed by high-resolution manometry. Sci Rep. 2017;7 :41436. doi: 10.1038/srep41436. PubMed PMID:28216670 PubMed Central PMC5316981.
  4. Quan, X, Yang, Z, Xue, M, Chen, JH, Huizinga, JD. Relationships between motor patterns and intraluminal pressure in the 3-taeniated proximal colon of the rabbit. Sci Rep. 2017;7 :42293. doi: 10.1038/srep42293. PubMed PMID:28195136 PubMed Central PMC5307310.
  5. Wei, R, Parsons, SP, Huizinga, JD. Network properties of interstitial cells of Cajal affect intestinal pacemaker activity and motor patterns, according to a mathematical model of weakly coupled oscillators. Exp. Physiol. 2017;102 (3):329-346. doi: 10.1113/EP086077. PubMed PMID:28036151 .
  6. Mikkelsen, HB, Huizinga, JD, Larsen, JO, Kirkeby, S. Ionized calcium-binding adaptor molecule 1 positive macrophages and HO-1 up-regulation in intestinal muscularis resident macrophages. Anat Rec (Hoboken). 2017;300 (6):1114-1122. doi: 10.1002/ar.23517. PubMed PMID:27860408 .
  7. Huizinga, JD. A Personal Perspective on the Development of Our Understanding of the Myogenic Control Mechanisms of Gut Motor Function. Adv. Exp. Med. Biol. 2016;891 :11-9. doi: 10.1007/978-3-319-27592-5_2. PubMed PMID:27379630 .
  8. Carr, EC, Watt-Watson, J, McGillion, M, Huizinga, A. The quest of pain education leaders in Canada and the United States: a qualitative study. J Adv Nurs. 2016;72 (11):2728-2737. doi: 10.1111/jan.13050. PubMed PMID:27322620 .
  9. Zhu, YF, Ungard, R, Seidlitz, E, Zacal, N, Huizinga, J, Henry, JL et al.. Differences in electrophysiological properties of functionally identified nociceptive sensory neurons in an animal model of cancer-induced bone pain. Mol Pain. 2016;12 :. doi: 10.1177/1744806916628778. PubMed PMID:27030711 PubMed Central PMC4994860.
  10. Zhu, YF, Wang, XY, Parsons, SP, Huizinga, JD. Stimulus-induced pacemaker activity in interstitial cells of Cajal associated with the deep muscular plexus of the small intestine. Neurogastroenterol. Motil. 2016;28 (7):1064-74. doi: 10.1111/nmo.12808. PubMed PMID:26968691 .
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