Premysl Bercik, MD

Associate Professor, Department of Medicine


  • Functional gastrointestinal diseases
  • Gastrointestinal motility
  • Visceral sensitivity
  • Gut-brain axis


  • The role of low-grade inflammation in the pathophysiology of gut dysfunction
  • The effect of gut inflammation on CNS function and gut-brain axis
  • The role of microbiota in functional GI diseases
  • Development of new techniques to study gastrointestinal motility, including videofluoroscopy image analysis and magnet-tracking
  • The role of antro-pyloro-duodenal coordination in gastroparesis
  • CIHR Grant “Intestinal Microbiota and Gut-Brain Axis”. Principle investigators: SM Collins and P Bercik. 2009-2014
  • AFMNet Grant: Determination of the efficacy and substantiation of health claims associated with prebiotics and their use in human nutrition; impacts on human physiology, well-being and gastro-intestinal communities. Co-investigator. Principle investigators: M Kalmokoff. 2009-2013
  • Crohn’s Colitis Foundation of Canada: “Intestinal Microbiota and the Increased Sensitivity to Colitis in Depression”. Principle investigator. 2009-2012
  • Industry sponsored grant: “Effect of N3001 on anxiety and depression in patients with diarrhea-predominant IBS: a pilot study”. Principle investigator. Sponsor: Nestec Ltd, Switzerland. 2009-2011
  • McMaster University Department of Medicine Internal Career Award. 2008-2011
  • AFP Internal Career Research Award, Department of Medicine, McMaster University. 2008-2011
  • Industry sponsored grant: “Mechanisms of action of N3001 on the gut-brain axis”. Co-investigator. Sponsor: Nestec Ltd, Switzerland. 2008-2010
  • Evaluation of effects of probiotics on gut and brain. Co-investigator, PI: SM Collins. Sponsor: Nestle Research Institute 2008-2009
  • Effect of probiotics on anxiety and depression in patients with diarrhea-predominant IBS. Principal Investigator. Nestle Research Institute. 2008-2009
  • Hamilton Health Sciences Young Investigator Research Award. 2005
  1. Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. -
    Caminero Alberto ,McCarville Justin L ,Galipeau Heather J ,Deraison Celine et al. - Nature communications. PubMed: PMID:30867416
  2. Response to Letter by Moulton et al. -
    Narula Neeraj ,Pinto-Sanchez Maria Ines ,Calo Natalia Causada ,Ford Alexander C ,Bercik Premsyl ,Reinisch Walter ,Moayyedi Paul - Inflammatory bowel diseases. PubMed: PMID:30824939
  3. Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins. -
    Caminero Alberto ,McCarville Justin L ,Zevallos Victor F ,Pigrau Marc et al. - Gastroenterology. PubMed: PMID:30802444
  4. Comparison of the metabolomic profiles of irritable bowel syndrome patients with ulcerative colitis patients and healthy controls: new insights into pathophysiology and potential biomarkers. -
    Keshteli Ammar Hassanzadeh ,Madsen Karen L ,Mandal Rupasri ,Boeckxstaens Guy E et al. - Alimentary pharmacology & therapeutics. PubMed: PMID:30706502
  5. Anxiety But Not Depression Predicts Poor Outcomes in Inflammatory Bowel Disease. -
    Narula Neeraj ,Pinto-Sanchez Maria Ines ,Calo Natalia Causada ,Ford Alexander C ,Bercik Premsyl ,Reinisch Walter ,Moayyedi Paul - Inflammatory bowel diseases. PubMed: PMID:30615113
  6. Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy. -
    Ivarsson Mattias E ,Durantie Estelle ,Huberli Corina ,Huwiler Samuel et al. - Cell chemical biology. PubMed: PMID:30482680
  7. Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry. -
    Chen Ji-Hong ,Parsons Sean P ,Shokrollahi Mitra ,Wan Andrew et al. - Frontiers in physiology. PubMed: PMID:30294277
  8. Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome. -
    Barbara Giovanni ,Grover Madhusudan ,Bercik Premysl ,Corsetti Maura ,Ghoshal Uday C ,Ohman Lena ,Rajilić-Stojanović Mirjana - Gastroenterology. PubMed: PMID:30009817
  9. High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production. -
    Miranda Pedro M ,De Palma Giada ,Serkis Viktoria ,Lu Jun et al. - Microbiome. PubMed: PMID:29566748
  10. Reply. -
    Pinto Sanchez Maria Ines ,Moayyedi Paul ,Bercik Premysl - Gastroenterology. PubMed: PMID:29351832
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