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Premysl Bercik, MD

Associate Professor, Department of Medicine

Email: bercikp@mcmaster.ca

  • Functional gastrointestinal diseases
  • Gastrointestinal motility
  • Visceral sensitivity
  • Gut-brain axis

Focus

  • The role of low-grade inflammation in the pathophysiology of gut dysfunction
  • The effect of gut inflammation on CNS function and gut-brain axis
  • The role of microbiota in functional GI diseases
  • Development of new techniques to study gastrointestinal motility, including videofluoroscopy image analysis and magnet-tracking
  • The role of antro-pyloro-duodenal coordination in gastroparesis
  • CIHR Grant “Intestinal Microbiota and Gut-Brain Axis”. Principle investigators: SM Collins and P Bercik. 2009-2014
  • AFMNet Grant: Determination of the efficacy and substantiation of health claims associated with prebiotics and their use in human nutrition; impacts on human physiology, well-being and gastro-intestinal communities. Co-investigator. Principle investigators: M Kalmokoff. 2009-2013
  • Crohn’s Colitis Foundation of Canada: “Intestinal Microbiota and the Increased Sensitivity to Colitis in Depression”. Principle investigator. 2009-2012
  • Industry sponsored grant: “Effect of N3001 on anxiety and depression in patients with diarrhea-predominant IBS: a pilot study”. Principle investigator. Sponsor: Nestec Ltd, Switzerland. 2009-2011
  • McMaster University Department of Medicine Internal Career Award. 2008-2011
  • AFP Internal Career Research Award, Department of Medicine, McMaster University. 2008-2011
  • Industry sponsored grant: “Mechanisms of action of N3001 on the gut-brain axis”. Co-investigator. Sponsor: Nestec Ltd, Switzerland. 2008-2010
  • Evaluation of effects of probiotics on gut and brain. Co-investigator, PI: SM Collins. Sponsor: Nestle Research Institute 2008-2009
  • Effect of probiotics on anxiety and depression in patients with diarrhea-predominant IBS. Principal Investigator. Nestle Research Institute. 2008-2009
  • Hamilton Health Sciences Young Investigator Research Award. 2005
  1. Letter: NICE referral criteria for lower gastrointestinal alarm features - not ideal but not poor either. Authors' reply. - 2017
    Simpkins S J ,Pintos-Sanchez M I ,Moayyedi P ,Bercik P ,Morgan D G ,Bolino C ,Ford A C - Alimentary pharmacology & therapeutics. PubMed: PMID:28326581
  2. Proton pump inhibitors for functional dyspepsia. - 2017
    Pinto-Sanchez Maria Ines ,Yuan Yuhong ,Bercik Premysl ,Moayyedi Paul - The Cochrane database of systematic reviews. PubMed: PMID:28271513
  3. Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. - 2017
    De Palma Giada ,Lynch Michael D J ,Lu Jun ,Dang Vi T et al. - Science translational medicine. PubMed: PMID:28251905
  4. Derivation and validation of a diagnostic test for irritable bowel syndrome using latent class analysis. - 2017
    Sood R ,Gracie D J ,Gold M J ,To N et al. - Alimentary pharmacology & therapeutics. PubMed: PMID:28105700
  5. Minimal differences in prevalence and spectrum of organic disease at upper gastrointestinal endoscopy between selected secondary care patients with symptoms of gastro-oesophageal reflux or dyspepsia. - 2016
    Irvine Andrew J ,Pinto-Sanchez Maria Ines ,Bercik Premysl ,Moayyedi Paul ,Ford Alexander C - Scandinavian journal of gastroenterology. PubMed: PMID:27973922
  6. No Difference Between Latiglutenase and Placebo in Reducing Villous Atrophy or Improving Symptoms in Patients With Symptomatic Celiac Disease. - 2016
    Murray Joseph A ,Kelly Ciarán P ,Green Peter H R ,Marcantonio Annette ,Wu Tsung-Teh ,Mäki Markku ,Adelman Daniel C , - Gastroenterology. PubMed: PMID:27864127
  7. Poor predictive value of lower gastrointestinal alarm features in the diagnosis of colorectal cancer in 1981 patients in secondary care. - 2016
    Simpkins S J ,Pinto-Sanchez M I ,Moayyedi P ,Bercik P ,Morgan D G ,Bolino C ,Ford A C - Alimentary pharmacology & therapeutics. PubMed: PMID:27807884
  8. Acetylcholine-producing T cells in the intestine regulate antimicrobial peptide expression and microbial diversity. - 2016
    Dhawan Shobhit ,De Palma Giada ,Willemze Rose A ,Hilbers Francisca W et al. - American journal of physiology. Gastrointestinal and liver physiology. PubMed: PMID:27514477
  9. Bifidobacterium infantis NLS Super Strain Reduces the Expression of α-Defensin-5, a Marker of Innate Immunity, in the Mucosa of Active Celiac Disease Patients. - 2016
    Pinto-Sánchez Maria I ,Smecuol Edgardo C ,Temprano Maria P ,Sugai Emilia et al. - Journal of clinical gastroenterology. PubMed: PMID:27636409
  10. Altered Esophageal Mucosal Structure in Patients with Celiac Disease. - 2016
    Pinto-Sánchez María Inés ,Nachman Fabio D ,Fuxman Claudia ,Iantorno Guido et al. - Canadian journal of gastroenterology & hepatology. PubMed: PMID:27446827
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