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Richard Hunt, FRCP, FRCPEd, FRCP(C), FACG, AGAF

Emeritus Professor, Department of Medicine

Email: huntr@mcmaster.ca

  • Pathophysiology of acid related disorders
  • Clinical pharmacology of treatment of gastrointestinal disease

Focus

At the basic level, studies include the physiological control of the parietal and chief cell, and the muscularis mucosae and more recently the immunophysiological interactions and cytokines involved in Helicobacter pylori infection. At the clinical level, research is focused on the pharmacology of treatment and the management strategies for all acid related disorders and especially Helicobacter pylori infection. Applied studies investigate the optimal control of acid secretion by 24 hour intra-gastric pH monitoring and other pharmacokinetic and pharmacodynamic effects as well as drug disposition studies. Extensive clinical trials are also conducted in PUD and GERD. The clinical group also applies extensive meta-analysis techniques to trials of treatment in ulcer related disease. Recent clinical studies of the gut-brain-gut axis have studied the role of the afferent and efferent nervous system employing evoked potentials from the esophagus recorded from the vagus nerve and EEG mapping.

  1. Hunt, RH, Yaghoobi, M. The Esophageal and Gastric Microbiome in Health and Disease. Gastroenterol. Clin. North Am. 2017;46 (1):121-141. doi: 10.1016/j.gtc.2016.09.009. PubMed PMID:28164846 .
  2. Fallone, CA, Gisbert, JP, Chiba, N, Veldhuyzen van Zanten, S, Fischbach, L, Hunt, RH et al.. Reply. Gastroenterology. 2017;152 (1):303-304. doi: 10.1053/j.gastro.2016.11.036. PubMed PMID:27893977 .
  3. Bhatt, DL, Hunt, RH. Concurrent Lower Gastrointestinal Bleeding Risk and Myocardial Ischemic Risk: Resume Aspirin or Not?. Gastroenterology. 2016;151 (2):222-5. doi: 10.1053/j.gastro.2016.06.033. PubMed PMID:27374367 .
  4. Fallone, CA, Chiba, N, van Zanten, SV, Fischbach, L, Gisbert, JP, Hunt, RH et al.. The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults. Gastroenterology. 2016;151 (1):51-69.e14. doi: 10.1053/j.gastro.2016.04.006. PubMed PMID:27102658 .
  5. Lyons, CL, Oliver, SV, Hunt, RH, Coetzee, M. The Influence of Insecticide Resistance, Age, Sex, and Blood Feeding Frequency on Thermal Tolerance of Wild and Laboratory Phenotypes of Anopheles funestus (Diptera: Culicidae). J. Med. Entomol. 2016;53 (2):394-400. doi: 10.1093/jme/tjv196. PubMed PMID:26718714 .
  6. Jedd, K, Hunt, RH, Cicchetti, D, Hunt, E, Cowell, RA, Rogosch, FA et al.. Long-term consequences of childhood maltreatment: Altered amygdala functional connectivity. Dev. Psychopathol. 2015;27 (4 Pt 2):1577-89. doi: 10.1017/S0954579415000954. PubMed PMID:26535945 PubMed Central PMC4635964.
  7. Hunt, RH, Scarpignato, C. Potassium-Competitive Acid Blockers (P-CABs): Are They Finally Ready for Prime Time in Acid-Related Disease?. Clin Transl Gastroenterol. 2015;6 :e119. doi: 10.1038/ctg.2015.39. PubMed PMID:26513137 PubMed Central PMC4816037.
  8. Scarpignato, C, Hunt, RH. Editorial: towards extended acid suppression--the search continues. Aliment. Pharmacol. Ther. 2015;42 (8):1027-9. doi: 10.1111/apt.13384. PubMed PMID:26374257 .
  9. Hunt, RH, Camilleri, M, Crowe, SE, El-Omar, EM, Fox, JG, Kuipers, EJ et al.. The stomach in health and disease. Gut. 2015;64 (10):1650-68. doi: 10.1136/gutjnl-2014-307595. PubMed PMID:26342014 PubMed Central PMC4835810.
  10. Cullen, KR, LaRiviere, LL, Vizueta, N, Thomas, KM, Hunt, RH, Miller, MJ et al.. Brain activation in response to overt and covert fear and happy faces in women with borderline personality disorder. Brain Imaging Behav. 2016;10 (2):319-31. doi: 10.1007/s11682-015-9406-4. PubMed PMID:26007149 .
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