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Richard Hunt, FRCP, FRCPEd, FRCP(C), FACG, AGAF

Emeritus Professor, Department of Medicine

Email: huntr@mcmaster.ca

  • Pathophysiology of acid related disorders
  • Clinical pharmacology of treatment of gastrointestinal disease

Focus

At the basic level, studies include the physiological control of the parietal and chief cell, and the muscularis mucosae and more recently the immunophysiological interactions and cytokines involved in Helicobacter pylori infection. At the clinical level, research is focused on the pharmacology of treatment and the management strategies for all acid related disorders and especially Helicobacter pylori infection. Applied studies investigate the optimal control of acid secretion by 24 hour intra-gastric pH monitoring and other pharmacokinetic and pharmacodynamic effects as well as drug disposition studies. Extensive clinical trials are also conducted in PUD and GERD. The clinical group also applies extensive meta-analysis techniques to trials of treatment in ulcer related disease. Recent clinical studies of the gut-brain-gut axis have studied the role of the afferent and efferent nervous system employing evoked potentials from the esophagus recorded from the vagus nerve and EEG mapping.

  1. Herzberg, MP, Hodel, AS, Cowell, RA, Hunt, RH, Gunnar, MR, Thomas, KM et al.. Risk taking, decision-making, and brain volume in youth adopted internationally from institutional care. Neuropsychologia. 2018;119 :262-270. doi: 10.1016/j.neuropsychologia.2018.08.022. PubMed PMID:30170080 .
  2. Inadomi, J, Alastal, H, Bonavina, L, Gross, S, Hunt, RH, Mashimo, H et al.. Recent advances in Barrett's esophagus. Ann. N. Y. Acad. Sci. 2018; :. doi: 10.1111/nyas.13909. PubMed PMID:29974975 .
  3. Dhaliwal, SK, Hunt, RH, Armstrong, D. Communicating Gastrointestinal Symptoms: The Patient's Challenge. Crit Rev Biomed Eng. 2018;46 (1):83-92. doi: 10.1615/CritRevBiomedEng.2018025987. PubMed PMID:29717678 .
  4. Lanas, A, Dumonceau, JM, Hunt, RH, Fujishiro, M, Scheiman, JM, Gralnek, IM et al.. Non-variceal upper gastrointestinal bleeding. Nat Rev Dis Primers. 2018;4 :18020. doi: 10.1038/nrdp.2018.20. PubMed PMID:29671413 .
  5. Demers, LA, McKenzie, KJ, Hunt, RH, Cicchetti, D, Cowell, RA, Rogosch, FA et al.. Separable Effects of Childhood Maltreatment and Adult Adaptive Functioning on Amygdala Connectivity During Emotion Processing. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3 (2):116-124. doi: 10.1016/j.bpsc.2017.08.010. PubMed PMID:29529406 PubMed Central PMC5851478.
  6. Wilson, S, Malone, SM, Hunt, RH, Thomas, KM, Iacono, WG. Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. Psychol Med. 2018;48 (10):1673-1684. doi: 10.1017/S0033291717003166. PubMed PMID:29108528 PubMed Central PMC5938157.
  7. Bastaki, SMA, Padol, IT, Amir, N, Hunt, RH. Effect of Aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E and thromboxane A levels in the anaesthetized rats in vivo. Mol. Cell. Biochem. 2018;438 (1-2):25-34. doi: 10.1007/s11010-017-3110-1. PubMed PMID:28766164 .
  8. Westlund Schreiner, M, Klimes-Dougan, B, Mueller, BA, Eberly, LE, Reigstad, KM, Carstedt, PA et al.. Multi-modal neuroimaging of adolescents with non-suicidal self-injury: Amygdala functional connectivity. J Affect Disord. 2017;221 :47-55. doi: 10.1016/j.jad.2017.06.004. PubMed PMID:28628767 PubMed Central PMC5555154.
  9. Rugge, M, Genta, RM, Di Mario, F, El-Omar, EM, El-Serag, HB, Fassan, M et al.. Gastric Cancer as Preventable Disease. Clin. Gastroenterol. Hepatol. 2017;15 (12):1833-1843. doi: 10.1016/j.cgh.2017.05.023. PubMed PMID:28532700 .
  10. Yaghoobi, M, McNabb-Baltar, J, Bijarchi, R, Hunt, RH. What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis. World J. Gastroenterol. 2017;23 (13):2435-2442. doi: 10.3748/wjg.v23.i13.2435. PubMed PMID:28428723 PubMed Central PMC5385410.
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