A consequence of long-standing heartburn is damage to the lining of the esophagus and its transformation. This is known as Barrett’s esophagus and it is a major risk factor for esophageal cancer.  Patients with celiac disease and gluten sensitivity more commonly experience reflux and may have higher rates of Barrett’s esophagus than individuals without sensitivity to gluten. 

This study is being conducted to understand how a 1-month gluten free diet will helps improve upper digestive symptoms in patients with celiac disease or gluten sensitivity.


Who is eligible to participate?

  • Adult patients (≥18 years old)

  • Reflux symptoms (heartburn, chest pain, regurgitation of food our sour liquid) and/or diagnosis of Barrett’s esophagus.

  • On a gluten containing diet


Will there be any samples being collected?

  • Two blood samples

  • Two stool samples


What is the total duration of the study and the number of visits?

  • Duration of visits: 5-6 weeks

  • Number of Visits: 5 visits/appointments at McMaster Children’s Hospital, Hamilton


Will there be a compensation to participate?

We will offer compensation and all the costs for the study visits will be covered.

If you think you can be eligible for this study, please contact us, we will be happy to hear from you!


Contact us to know further information about the study

Gaston Rueda, MD – Clinical Research Fellow: ruedag@mcmaster.ca



Dr. Premysl Bercik (Principal Investigator), Dr. Gaston Rueda (research staff), Dr Pedro Miranda (research staff), Caroline Seiler (research staff)

The study has been approved by Hamilton Integrated Research Ethics Board – Study #:3002


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