The Diet in IBS Research Study is the first study to investigate the effects of dietary gluten and amylase trypsin inhibitors (ATIs) on irritable bowel syndrome (IBS). The trial is being led by Drs. Premysl Bercik and M. Ines Pinto-Sanchez in the Farncombe Digestive Disease Research Institute at McMaster University.
IBS is a common gastrointestinal disease with symptoms including constipation, diarrhea, gas, bloating, and abdominal pain for at least 3 months. IBS is difficult to treat because it is very diverse and it is likely that different subgroups of patients should have personalized treatments to help improve their symptoms. Many IBS patients experience symptoms after they eat certain foods, prompting them to avoid those foods. Some common “trigger foods” include dairy, eggs, beans, fried or fatty foods, alcohol, spicy foods, processed foods, and gluten.
A gluten-free diet is effective at improving symptoms in a proportion of IBS patients. However, it’s currently unknown whether gluten itself or other components of wheat are the cause for IBS symptoms. Amylase trypsin inhibitors (ATIs) are proteins that have been shown to activate the immune system in animal studies. They are found in all of the gluten-containing grains (wheat, rye, & barley), so it may be that ATIs cause or enhance IBS symptoms instead of gluten. ATIs do not have the same unique baking properties of gluten, so if they cause symptoms in patients then it would be possible to develop ATI-free flour for baking. This study will be the first to test whether ATIs or gluten cause symptoms in IBS.
6 visits over 7-10 weeks
6 blood samples, 6 urine samples, 6 stool samples, & 4 x-rays
We will offer compensation and parking passes will be provided
This study is supported by the Canadian Digestive Health Foundation and a Society for the Study of Celiac Disease (SSCD) grant for Non-Celiac Gluten/Wheat Sensitivity sponsored by the Nestle Research Center, Nestec SA to Drs. Bercik and Pinto-Sanchez.
Ms. Caroline Seiler, Dr. Premysl Bercik, Dr. Maria Ines Pinto-Sanchez, Dr. Elena Verdu, Dr. Stephen Collins, Dr. Paul Moayyedi, Dr. Andrea Nardelli, Dr. Detlef Schuppan, Dr. Pedro Miranda, Dr. Gaston Rueda, & Ms. Rajka Borojevic