Paul Moayyedi, BSc, MB ChB, PhD, MPH, FRCP, FRCPC, FACG, AGAF

Professor, Department of Medicine
Director of Clinical Research, Farncombe Family Digestive Health Research Institute
Director, Division of Gastroenterology


Health Services Research in Gastroenterology


Dr. Moayyedi has a strong interest in evidence based medicine. He qualified in Medicine from Bristol University, UK and obtained a PhD in Medicine as well as a Master’s in Public Health from the University of Leeds, UK. He was appointed Director of the Division of Gastroenterology in 2006. He has conducted a number of large randomized controlled trials and epidemiological studies that have evaluated functional and organic disease of the GI tract. He has also published several systematic reviews that have been influential in British, American and Canadian national guidelines. He is the joint Coordinating Editor for the Upper Gastrointestinal and Pancreatic Diseases Cochrane Review Group based at McMaster and is also Co-Editor-in-Chief of the American Journal of Gastroenterology.


Epidemiology, biostatistics, systematic review and meta-analysis, clinical trials, health economics, decision modeling.

Project 1

Title: Aspirin and PPIs to prevent mortality in Barrett’s patients
Funders: Cancer Research UK and AstraZeneca
Role: Deputy Principal Investigator
Duration: 2004-2014

Project 2

Title: Barrett’s esophagus two yearly surveillance vs. no surveillance: a randomized controlled trial to estimate cost-effectiveness (BOSS)
Funders: National NHS R&D HTA program
Role: Principal Investigator
Duration: 2008-2019

Project 3

Title: The Michael J. Howorth GEM Project
Funders: Crohn’s and Colitis Foundation of Canada
Role: GEM Executive Team
Duration: 2007-2013

Project 4

Title: Cohort study of inflammatory bowel disease after acute enteric infection in Walkerton, Ontario.
Funders: Crohn’s and Colitis Foundation of Canada
Role: Co-investigator (Principal Investigator Dr. John Marshall)
Duration: 2005-2008

  1. Jarde, A, Lewis-Mikhael, AM, Moayyedi, P, Stearns, JC, Collins, SM, Beyene, J et al.. Pregnancy outcomes in women taking probiotics or prebiotics: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2018;18 (1):14. doi: 10.1186/s12884-017-1629-5. PubMed PMID:29310610 PubMed Central PMC5759212.
  2. Moayyedi, P, Lewis, MA. Proton Pump Inhibitors and Dementia: Deciphering the Data. Am. J. Gastroenterol. 2017;112 (12):1809-1811. doi: 10.1038/ajg.2017.415. PubMed PMID:29215629 .
  3. Chan, AT, Moayyedi, P. Signature Celebration of Gastroenterology, Colorectal Cancer. Gastroenterology. 2017; :. doi: 10.1053/j.gastro.2017.11.029. PubMed PMID:29174953 .
  4. Pinto-Sanchez, MI, Yuan, Y, Hassan, A, Bercik, P, Moayyedi, P. Proton pump inhibitors for functional dyspepsia. Cochrane Database Syst Rev. 2017;11 :CD011194. doi: 10.1002/14651858.CD011194.pub3. PubMed PMID:29161458 .
  5. Moayyedi, P, Mearin, F, Azpiroz, F, Andresen, V, Barbara, G, Corsetti, M et al.. Irritable bowel syndrome diagnosis and management: A simplified algorithm for clinical practice. United European Gastroenterol J. 2017;5 (6):773-788. doi: 10.1177/2050640617731968. PubMed PMID:29026591 PubMed Central PMC5625880.
  6. Narula, N, Kassam, Z, Yuan, Y, Colombel, JF, Ponsioen, C, Reinisch, W et al.. Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis. Inflamm. Bowel Dis. 2017; :. doi: 10.1097/MIB.0000000000001228. PubMed PMID:28922255 .
  7. Narula, N, Kassam, Z, Yuan, Y, Colombel, JF, Ponsioen, C, Reinisch, W et al.. Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis. Inflamm. Bowel Dis. 2017;23 (10):1702-1709. doi: 10.1097/MIB.0000000000001228. PubMed PMID:28906291 .
  8. Moayyedi, P, Yuan, Y, Baharith, H, Ford, AC. Faecal microbiota transplantation for Clostridium difficile-associated diarrhoea: a systematic review of randomised controlled trials. Med. J. Aust. 2017;207 (4):166-172. . PubMed PMID:28814204 .
  9. Bosch, J, Eikelboom, JW, Connolly, SJ, Bruns, NC, Lanius, V, Yuan, F et al.. Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial. Can J Cardiol. 2017;33 (8):1027-1035. doi: 10.1016/j.cjca.2017.06.001. PubMed PMID:28754388 .
  10. Moayyedi, PM, Lacy, BE, Andrews, CN, Enns, RA, Howden, CW, Vakil, N et al.. ACG and CAG Clinical Guideline: Management of Dyspepsia. Am. J. Gastroenterol. 2017;112 (7):988-1013. doi: 10.1038/ajg.2017.154. PubMed PMID:28631728 .
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