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Paul Moayyedi, BSc, MB ChB, PhD, MPH, FRCP, FRCPC, FACG, AGAF

Professor, Department of Medicine
Director of Clinical Research, Farncombe Family Digestive Health Research Institute
Director, Division of Gastroenterology

Email: moayyep@mcmaster.ca

Health Services Research in Gastroenterology

Focus

Dr. Moayyedi has a strong interest in evidence based medicine. He qualified in Medicine from Bristol University, UK and obtained a PhD in Medicine as well as a Master’s in Public Health from the University of Leeds, UK. He was appointed Director of the Division of Gastroenterology in 2006. He has conducted a number of large randomized controlled trials and epidemiological studies that have evaluated functional and organic disease of the GI tract. He has also published several systematic reviews that have been influential in British, American and Canadian national guidelines. He is the joint Coordinating Editor for the Upper Gastrointestinal and Pancreatic Diseases Cochrane Review Group based at McMaster and is also Co-Editor-in-Chief of the American Journal of Gastroenterology.

Methodologies

Epidemiology, biostatistics, systematic review and meta-analysis, clinical trials, health economics, decision modeling.

Project 1

Title: Aspirin and PPIs to prevent mortality in Barrett’s patients
Funders: Cancer Research UK and AstraZeneca
Role: Deputy Principal Investigator
Duration: 2004-2014

Project 2

Title: Barrett’s esophagus two yearly surveillance vs. no surveillance: a randomized controlled trial to estimate cost-effectiveness (BOSS)
Funders: National NHS R&D HTA program
Role: Principal Investigator
Duration: 2008-2019

Project 3

Title: The Michael J. Howorth GEM Project
Funders: Crohn’s and Colitis Foundation of Canada
Role: GEM Executive Team
Duration: 2007-2013

Project 4

Title: Cohort study of inflammatory bowel disease after acute enteric infection in Walkerton, Ontario.
Funders: Crohn’s and Colitis Foundation of Canada
Role: Co-investigator (Principal Investigator Dr. John Marshall)
Duration: 2005-2008

  1. Narula, N, Kassam, Z, Yuan, Y, Colombel, JF, Ponsioen, C, Reinisch, W et al.. Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis. Inflamm. Bowel Dis. 2017; :. doi: 10.1097/MIB.0000000000001228. PubMed PMID:28922255 .
  2. Narula, N, Kassam, Z, Yuan, Y, Colombel, JF, Ponsioen, C, Reinisch, W et al.. Systematic Review and Meta-analysis: Fecal Microbiota Transplantation for Treatment of Active Ulcerative Colitis. Inflamm. Bowel Dis. 2017;23 (10):1702-1709. doi: 10.1097/MIB.0000000000001228. PubMed PMID:28906291 .
  3. Moayyedi, P, Yuan, Y, Baharith, H, Ford, AC. Faecal microbiota transplantation for Clostridium difficile-associated diarrhoea: a systematic review of randomised controlled trials. Med. J. Aust. 2017;207 (4):166-172. . PubMed PMID:28814204 .
  4. Bosch, J, Eikelboom, JW, Connolly, SJ, Bruns, NC, Lanius, V, Yuan, F et al.. Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial. Can J Cardiol. 2017;33 (8):1027-1035. doi: 10.1016/j.cjca.2017.06.001. PubMed PMID:28754388 .
  5. Moayyedi, PM, Lacy, BE, Andrews, CN, Enns, RA, Howden, CW, Vakil, N et al.. ACG and CAG Clinical Guideline: Management of Dyspepsia. Am. J. Gastroenterol. 2017;112 (7):988-1013. doi: 10.1038/ajg.2017.154. PubMed PMID:28631728 .
  6. Vakil, NB, Howden, CW, Moayyedi, P, Tack, J. White Paper AGA: Functional Dyspepsia. Clin. Gastroenterol. Hepatol. 2017;15 (8):1191-1194. doi: 10.1016/j.cgh.2017.05.013. PubMed PMID:28529164 .
  7. Farrell, B, Pottie, K, Thompson, W, Boghossian, T, Pizzola, L, Rashid, FJ et al.. Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline. Can Fam Physician. 2017;63 (5):354-364. . PubMed PMID:28500192 PubMed Central PMC5429051.
  8. Pinto-Sanchez, MI, Hall, GB, Ghajar, K, Nardelli, A, Bolino, C, Lau, JT et al.. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017;153 (2):448-459.e8. doi: 10.1053/j.gastro.2017.05.003. PubMed PMID:28483500 .
  9. Pinto-Sánchez, MI, Causada-Calo, N, Bercik, P, Ford, AC, Murray, JA, Armstrong, D et al.. Safety of Adding Oats to a Gluten-Free Diet for Patients With Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies. Gastroenterology. 2017;153 (2):395-409.e3. doi: 10.1053/j.gastro.2017.04.009. PubMed PMID:28431885 .
  10. Sood, R, Gracie, DJ, Gold, MJ, To, N, Pinto-Sanchez, MI, Bercik, P et al.. Editorial: latent class analysis to improve confidence in the diagnosis of IBS - authors' reply. Aliment. Pharmacol. Ther. 2017;45 (9):1268-1269. doi: 10.1111/apt.14012. PubMed PMID:28370047 .
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